(5)AstraZeneca Oncology, Innovative Medicines and Early … Learning from patients to make research participation less of a trial, Embracing the ethics of data and artificial intelligence (AI). Both types of artefact can lead to inaccurate and misleading data. After 21 days of WD, energy intake and absorption, EE, and body temperature were normalized. Head of Advanced Drug Delivery, Pharmaceutical Sciences, R&D, Senior Principal Scientist, Advanced Drug Delivery, Pharmaceutical Sciences, R&D. The Canadian Medical Hall of Fame presents its Discovery Days in Science program at University campuses across Canada, giving secondary school students and teachers the opportunity to explore a variety of career options in medicine and the health sciences sector. All Departments; 126 Documents; 10 Researchers; Identification of a novel asthma susceptibility gene on chromosome 1qter and its functional evaluation. The pharmaceutical industry has historically relied on high throughput screening as a cornerstone to identify chemical equity for drug discovery projects. We are continuing to design new ways to target the drivers of disease to help us create the next generation of therapeutics. Core body temperature and EE was increased between 48 and 72 h but normalized after 21 days on WD. Download. Publications 17. Calculations based on the correlation between locomotor activity and EE in 2-h intervals at days 21-23 indicated that a large portion of the higher body weight gain in the WD group could be attributed to the reduced locomotor activity. To achieve all we want to achieve, we cannot do it alone. 1,389. Diabetes, Cardiovascular disease, Energy Metabolism, Signal Transduction; Growth Hormone Overexpression in the Central Nervous System Results in Hyperphagia … Salary Competitive . Publications 18. by Mohammad Bohlooly-Y and +1. Publications. You are about to access AstraZeneca historic archive material. by Mark Wigglesworth • 20 . Our aim was to investigate the use of a one-step accelerated workflow to measure the levels of epidermal growth factor receptor (EGFR) and nuclear factor erythroid 2 (NF-E2)-related factor 2 (Nrf2) gene expression using lysates generated by the RealTime ready Cell Lysis kit in downstream quantitative RT-qPCR. To learn more, view our, Identification of a novel asthma susceptibility gene on chromosome 1qter and its functional evaluation, The Orphan G Protein-coupled Receptors GPR41 and GPR43 Are Activated by Propionate and Other Short Chain Carboxylic Acids, Screening  -Arrestin Recruitment for the Identification of Natural Ligands for Orphan G-Protein-Coupled Receptors, The Discovery of a Selective, Small Molecule Agonist for the Mas-Related Gene X1 Receptor, Novel Spirotetracyclic Zwitterionic Dual H 1 /5-HT 2A Receptor Antagonists for the Treatment of Sleep Disorders, ChemInform Abstract: Novel Imidazobenzazepine Derivatives as Dual H1/5-HT2A Antagonists for the Treatment of Sleep Disorders, A salt bridge between Arg-20 on parathyroid hormone (PTH) and Asp-137 on the PTH1 receptor is essential for full affinity, Increasing the delivery of next generation therapeutics from high throughput screening libraries, Artefacts at the liquid interface and their impact in miniaturized biochemical assay, Novel Spirotetracyclic Zwitterionic Dual H1/5-HT2A Receptor Antagonists for the Treatment of Sleep Disorders, Validation of Miniaturized One-Step Reverse Transcription qPCR Assays for High-Throughput Screening and Comparison to a Reporter Gene Methodology, Ghrelin increases intake of rewarding food in rodents, Growth hormone receptor deficiency results in blunted ghrelin feeding response, obesity, and hypolipidemia in mice, Central NMU signaling in body weight and energy balance regulation: evidence from NMUR2 deletion and chronic central NMU treatment in mice, Acutely reduced locomotor activity is a major contributor to Western diet-induced obesity in mice, Mice with experimental colitis show an altered metabolism with decreased metabolic rate, Importance of melanin-concentrating hormone receptor for the acute effects of ghrelin, G protein-coupled receptor 12 deficiency results in dyslipidemia and obesity in mice, Phenotypic screening of hepatocyte nuclear factor (HNF) 4-γ receptor knockout mice, GPR10 deficiency in mice results in altered energy expenditure and obesity. By using our site, you agree to our collection of information through the use of cookies. After I completed my PhD in Computational Chemistry at the University of Lund and postdoctoral research at the University of Cambridge and the Czech Academy of Sciences, I joined AstraZeneca in 2004. The acute reduction in locomotor activity was observed after only 3-5 h on WD. Thus, we provide the first evidence that long-term central NMU treatment reduces body weight, food intake, and adiposity and that central NMUR2 signaling is required for these effects in female but not male mice. The energy intake and energy absorption were increased during the first 24 h, lower after 72 h, and normalized between 7 and 14 days on WD compared with mice given chow diet. The Commercial Information Architecture (CIA) role is to connect all AstraZeneca business processes and functions to enable and promote a closed loop business process. 3,137. The aim of the present study was to investigate the short- and long-term effects of a high-fat Western diet (WD) on intake, storage, expenditure, and fecal loss of energy as well as effects on locomotor activity and thermogenesis. AstraZeneca is a leader in Oncology with a global footprint and ability to deliver best in class medicines both small and large molecules to the market. A more efficient drug discovery and development process utilizing AI not only reduces the time taken to get a viable product to market but cuts costs. About. Herein, we report the discovery of two diverse lead series imidazo[1,2-a]pyridine ethers (IPE) and squaramides (SQA) as inhibitors of mycobacterial ATP-synthesis. There is a wide literature that describes HTS and fragment based screening approaches which offer clear direction on the process for these two distinct activities. PTH's interaction with the N-terminal domain of PTH1 is mediated in part by Arg-20 on the peptide which forms a number of... Parathyroid hormone (PTH) acts via the receptor PTH1 and plays an important role in calcium homeostasis. Publications 47. Our commitment to science is reflected in our track record of publications. Enter the email address you signed up with and we'll email you a reset link. The artefacts described here due to reagents partitioning into the carrier oil or protein binding at the water-oil interface significantly impact the potential use of these microfluidic systems as a means to carry out miniaturized biological assays, and further work is needed to understand the impact and reduction of these phenomena. In diet-induced obese male and female C57BL/6 mice, icv infusion of NMU (8 microg x day(-1) x mouse(-1)) for 7 days decreased body weight and total energy intake compared with vehicle treatment. I get knowledge about how the algorithms … Reads . In addition to the reduction in costs, this technology can also reduce evaporation and contamination which are often problems seen in miniaturized microtitre plate formats. Compared with controls, GHR-/- mice had increased food intake, leptin levels, and total and intra-abdominal fat mass per body weight and deceased lean mass. Discovery Sciences. We combine a unique range of knowledge, skills and experience with a passion for following the science. Leading scientific expertise. VP and Head of Genome Analytics & Bioinformatics, Centre for Genomics Research, Discovery Sciences, R&D. You have selected a link that will take you to a site maintained by a third party who is solely responsible for its contents. Discovery Sciences. 47. Data Science and AI have the potential to transform the way we discover and develop new medicines. AstraZeneca is a huge advocate of scientific early careers, providing extensive opportunities to learn side-by-side with a diverse team of therapy area world leading experts at the cutting-edge of research. PhD. Network. We are never complacent about scientific discovery and development, always pushing our R&D productivity, searching for new knowledge and the next breakthrough. Publications 33. We present, for the first time, data from a vendor-independent one-step 1536 workflow that compares reporter gene and RT-qPCR screening approaches for oncology drug discovery. 1,978 . Discovery Sciences. Senior Vice President and … The pharmaceutical industry has historically relied on high throughput screening as a cornerstone to identify chemical equity for drug discovery projects. About. Projects 1. 1 Oncology and Discovery Sciences R&D , AstraZeneca , Darwin Building and Hodgkin Building, c/o Darwin Building, 310 Cambridge Science Park, Milton Rd , Cambridge CB4 0WG , U.K. 2 Chemical Development, Pharmaceutical Technology & Development , AstraZeneca , Macclesfield Campus, Macclesfield SK10 2NA , U.K. 18. In this paper, we present a study of the partitioning of a number of drug-like molecules in a range of oils and evidence of protein binding at the water-oil interface which results in reduced activity of a cytochrome P450 enzyme. About. These one-step reagents enable the user to go straight from a cellular assay format to qPCR without the need for cumbersome and potentially expensive multistep RNA purification protocols. About. Quantitative real-time polymerase chain reaction (PCR) is regarded as the gold standard for molecular profiling and target identification, but not in the context of high-throughput screening owing to limitations on workflow, cost of... Quantitative real-time polymerase chain reaction (PCR) is regarded as the gold standard for molecular profiling and target identification, but not in the context of high-throughput screening owing to limitations on workflow, cost of reagents, and miniaturization opportunities. After taking over as chief executive of AstraZeneca in 2012, Pascal Soriot sent a team to a global life sciences conference to look for potential drug discovery partners. The novel 7-transmembrane receptor MrgX1 is located predominantly in the dorsal root ganglion and has consequently been implicated in the perception of pain. Moreover, serum levels of triglycerides, LDL and HDL cholesterol, and apoB, as well as glucose and insulin levels were lower in the GHR-/- mice. A paper detailing the discovery was published in the 'Journal of Orthoptera Research' in February. The novel 7-transmembrane receptor MrgX1 is located predominantly in the dorsal root ganglion and has consequently been implicated in the perception of pain. They needed a platform that enabled them to build scalable, performant data pipelines that feed machine learning … Long-term GHR deficiency in mice is associated with high plasma leptin levels, obesity, and increased food intake but a marked decrease in all lipoprotein fractions. About. Reads . Click ‘cancel’ to return to AstraZeneca’s site or ‘continue’ to proceed. Our pioneering research identifies novel pathways through which the microbiome can impact outcomes … (4)AstraZeneca, Discovery Sciences, Innovative Medicines and Early Development Biotech Unit, Pepparedsleden 1, Mölndal 431 83, Sweden. About. In addition, female (but not male) NMUR2-null mice had increased body weight and body fat mass when fed a high-fat diet but lacked a clear body weight phenotype when fed a standard diet compared with wild-type littermates. Master of Science. In the last five years, we have invested more than 25 billion dollars in research and development (as of 2019). Please refer to your approved national product label (SmPC) for current product information. CIA has a hub-and-spoke form with a centralized architecture. Reads . Despite these advantages, we currently advise caution in the use of these microfluidic approaches as there remains a lack of understanding of the artefacts of the systems such as reagent partitioning from droplet to carrier oil and interaction of the biological reagents with the water-oil interface. Genetics, Polymorphism, Asthma, Adolescent; The Orphan G Protein-coupled Receptors GPR41 and GPR43 Are Activated by Propionate and Other Short Chain … This website is intended for people seeking information on AstraZeneca's worldwide business. Parathyroid hormone (PTH) acts via the receptor PTH1 and plays an important role in calcium homeostasis. In our quest to transform disease, we believe it is essential to target novel biology we uncover. I have read this warning and will not be using any of the contained product information for clinical purposes. Jonathan Wingfield | 15 April 2013 AstraZeneca | Innovative Medicines | Discovery Sciences If you think you have a suitable project .… •Please complete the outline project proposal slide •Return the slide to jonathan.wingfield@astrazeneca.com thbefore 30 May 2013 •All returned project proposals will be reviewed within AZ and feedback will be provided •AZ will contact selected project proposers by 15th … Contact. At AstraZeneca, our drug discovery and development is guided by our ‘5R Framework’: right target, right patient, right tissue, right safety, right commercial potential. We have three strategic R&D centres in the UK, US and Sweden, as well as an active R&D presence in 40 other countries spanning the globe. The Discovery Sciences Department at AstraZeneca on Academia.edu About. These changes paralleled plasma T(3) levels and uncoupling protein-1 expression in brown adipose tissue. 8 Drug Safety and Metabolism, IMED Biotech Unit, AstraZeneca, 35 Gatehouse Drive, Waltham, Massachusetts 02451, USA. Read about our approach to R&D. However, few people have considered how best to identify medium to low molecular weight compounds from large diversity screening sets and increase downstream success. Team Leader, Research and Early Development, Respiratory, Inflammation & Autoimmunity (RIA), BioPharmaceuticals R&D. Any reference in these archives to AstraZeneca products or their uses may not reflect current medical knowledge and should not be used as a source of information on the present product label, efficacy data or safety data. Established the in vitro and in vivo TB research infrastructure and expertise at AstraZeneca India; Pioneered the PK/PD science for anti-TB drugs; Led the discovery of the first drug candidate from AstraZeneca for the treatment of tuberculosis; Worked extensively with a cross-disciplinary and trans-national team of scientists within & outside AstraZeneca and established collaborations with several … However, with pharmaceutical companies moving through a phase of diminished returns and alternative hit identification strategies proving successful, it is more important than ever to understand how this approach can be used more effectively to increase the delivery of next generation therapeutics from high throughput screening libraries. We have a passion for discovery and we’re constantly pushing the boundaries of science to deliver life-changing medicines to patients. To investigate the role of the central neuromedin U (NMU) signaling system in body weight and energy balance regulation, we examined the effects of long-term intracerebroventricular (icv) infusion of NMU in C57Bl/6 mice and in mice... To investigate the role of the central neuromedin U (NMU) signaling system in body weight and energy balance regulation, we examined the effects of long-term intracerebroventricular (icv) infusion of NMU in C57Bl/6 mice and in mice lacking the gene encoding NMU receptor 2. Veeva ID: Z4-25396Date of next review: August 2022. AstraZeneca is a global, science led biopharmaceutical business and our innovative medicines are used by millions of patients worldwide. Discovery Sciences (Mike Snowden (07016428)) (10000846) 15 Early CVRM (Regina Fritsche Danielson (05016741)) (10000844) 11 Early Oncology (Susan Galbraith (07016555)) (10000845) 63 Droplet microfluidic technology has the potential to significantly reduce reagent use, and therefore, lower costs of assays employed in drug discovery campaigns. For many participants, this experience helps to set them on a path to pursue post …
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